Marquis (15% w/w Ponazuril) Antiprotozoal Oral Paste for Horses, 127 g

Marquis Oral Paste is a specialized veterinary antiprotozoal therapeutic formulation engineered for the targeted treatment of Equine Protozoal Myeloencephalitis (EPM) in horses. Containing the active triazinetrione anticoccidial compound ponazuril, this professional-grade medication crosses the blood-brain barrier to disrupt the protozoal parasite Sarcocystis neurona, halting its replication within the central nervous system. Because EPM is a severe neurological disease requiring precise medical intervention, administration must be guided by accurate veterinary diagnosis and strict adherence to clinical dosing protocols.

What Is Marquis Oral Paste?

Marquis is a specialized veterinary anti-parasitic compound formulated for oral delivery under professional veterinary supervision.

Active Ingredients and Formulation

• Active Component: Ponazuril at a concentration of 15% weight-by-weight (15% w/w). It acts as a potent protozoalcidal agent that structurally targets the apicoplast of Sarcocystis neurona, effectively killing the organism responsible for central nervous system lesions.

• Vehicle and Presentation: Supplied as a palatable, white-to-yellowish oral paste packaged in a calibrated 127 g dosing syringe with an adjustable ring-stop plunger for precise, weight-based administration.

What Is It Used For?

Primary Veterinary Indications

• Equine Protozoal Myeloencephalitis (EPM): Routinely prescribed by equine veterinarians as the standard treatment for clinical EPM caused by Sarcocystis neurona in horses.

• Neurological Support: Helps arrest the progression of spinal cord and brain lesions, improving coordination, balance, and muscle symmetry in affected equines.

Administration and Dosage Considerations

Route and Dosing

• Route of Administration: Administered orally by placing the syringe nozzle into the interdental space and depositing the paste onto the back of the tongue.

• Standard Equine Dosage Reference: Typically administered at a recommended daily dose of 5 mg per kg (2.27 mg per lb) of body weight once daily for 28 consecutive days.

• Administration Protocol: Adjust the syringe plunger ring-stop to the correct weight marking corresponding to the horse’s verified body weight. Ensure the horse has no feed in its mouth prior to dosing to guarantee complete ingestion.

• Veterinary Supervision: Treatment duration and diagnostic follow-up must be managed exclusively by a licensed veterinarian.

Important Safety Information

• Contraindications: Do not administer to horses with known hypersensitivity to ponazuril. Safety in breeding stallions, pregnant mares, or nursing foals has not been thoroughly evaluated.

• Side Effects and Precautions: Generally exceptionally well tolerated. Occasional side effects may include localized skin rashes or blisters around the mouth (contact dermatitis), loose stools, or mild colic symptoms. Discontinue use and consult a veterinarian if severe adverse signs develop.

• Withdrawal Periods: Observe mandatory meat withdrawal intervals established by regulatory authorities if treating food-producing equines intended for human consumption (typically 21 days following the final dose, depending on regional regulations).

• Professional Guidance: Due to the complex neurological nature of EPM, use must be supervised under direct veterinary clinical oversight.

Storage and Handling

• Store at controlled room temperature between 15°C and 30°C (59°F to 86°F). Avoid freezing and excessive heat.

• Replace the protective cap securely after each daily use.

• Keep securely out of reach of children, unauthorized individuals, and animals at all times.

Frequently Asked Questions

What is Marquis Oral Paste used for?

It is a professional equine antiprotozoal paste utilized to treat Equine Protozoal Myeloencephalitis (EPM) caused by Sarcocystis neurona.

What is the active ingredient?

It contains ponazuril at 15% w/w, which acts as a protozoalcidal agent to eliminate parasites within the central nervous system.

How is Marquis administered?

It is administered orally once daily at a dose of 5 mg/kg for 28 consecutive days using the calibrated dosing syringe under veterinary supervision.

Order Rx Marquis Oral Paste Online

Rx Marquis (15% w/w Ponazuril) Antiprotozoal Oral Paste (127 g) is available for order through our platform subject to veterinary prescription verification and regulatory compliance. For assistance regarding prescription submission, stock availability, or secure shipping protocols, please contact our customer support team.