Simparica Trio (Sarolaner, Moxidectin, and Pyrantel) Chewable Tablets for Dogs

Simparica Trio Chewable Tablets are a broad-spectrum veterinary antiparasitic medication formulated for oral administration in dogs to provide comprehensive, monthly protection against heartworm disease, fleas, ticks, and intestinal roundworms and hookworms. Containing three active pharmacological agents—sarolaner, moxidectin, and pyrantel—this professional-grade veterinary preparation offers simultaneous systemic and gastrointestinal parasite control in a single, highly palatable liver-flavored chew. Because proactive parasite prevention requires weight-appropriate dosing and regular veterinary guidance, administration must follow strict product labeling and clinical recommendations.

What Is Simparica Trio?

Simparica Trio is a specialized veterinary combination parasiticidal compound formulated for monthly oral delivery under professional veterinary supervision.

Active Ingredients and Formulation

• Active Components:

  • Sarolaner: An isoxazoline ectoparasiticide that kills adult fleas and treats/controls tick infestations (Ixodes scapularis, Amblyomma americanum, Dermacentor variabilis, Rhipicephalus sanguineus, and Amblyomma maculatum).

  • Moxidectin: A macrocyclic lactone endoparasiticide that prevents heartworm disease caused by Dirofilaria immitis.

  • Pyrantel (as pyrantel pamoate): An anthelmintic that treats and controls intestinal roundworms (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala).

• Vehicle and Presentation: Supplied as savory, meat-flavored chewable tablets packaged in blister packs of 6 counts, formulated across distinct weight tiers to ensure accurate dosing for dogs ranging from 2.8 lbs to over 132 lbs.

What Is It Used For?

Primary Veterinary Indications

• Heartworm Disease Prevention: Routinely prescribed by veterinarians to prevent fatal canine heartworm disease caused by Dirofilaria immitis.

• Flea Infestation Control: Rapidly kills newly emerged fleas before they can lay eggs, providing effective treatment and prevention of flea infestations.

• Tick Management: Eliminates and controls five common tick species, reducing the risk of tick-borne pathogen transmission.

• Intestinal Parasite Elimination: Treats and controls dangerous gastrointestinal hookworm and roundworm infections.

Administration and Dosage Considerations

Route and Dosing

• Route of Administration: Administered orally once a month, preferably given with or without food. The chew is highly palatable and typically accepted voluntarily by dogs.

• Weight-Based Dosing Tiers:

  • 2.8 to 5.1 lbs (Yellow pack)

  • 5.2 to 11.0 lbs (Purple pack)

  • 11.1 to 22.0 lbs (Orange pack)

  • 22.1 to 44.0 lbs (Green pack)

  • 44.1 to 88.0 lbs (Blue pack)

  • 88.1 to 132.0 lbs (Red pack)

• Veterinary Supervision: Dogs should be tested for existing heartworm infections prior to initiating a preventative program. Treatment must be administered year-round or as directed by a licensed veterinarian.

Important Safety Information

• Contraindications: Do not use in cats or other animal species. Do not administer to dogs with known hypersensitivity to sarolaner, moxidectin, or pyrantel. Use with caution in dogs with a history of neurological disorders, tremors, or seizures.

• Side Effects and Precautions: Generally exceptionally well tolerated. Occasional adverse reactions may include vomiting, diarrhea, lethargy, or decreased appetite. As an isoxazoline product, sarolaner has been rarely associated with neurologic signs such as tremors, ataxia, or seizures in susceptible dogs.

• Professional Guidance: Ensure dogs consume the entire chew and do not hide or lose portions of the dose to guarantee full therapeutic efficacy.

Storage and Handling

• Store at controlled room temperature between 15°C and 30°C (59°F to 86°F), with excursions permitted up to 40°C (104°F).

• Keep individual chewables stored in their protective blister packaging until ready for immediate administration.

• Keep securely out of reach of children, unauthorized individuals, and pets to prevent accidental overconsumption.

Complete Protection in One Dose

Simparica Trio contains three active ingredients—sarolaner, moxidectin, and pyrantel—that provide complete protection. Whether it’s fleas, ticks, hookworms, or heartworm prevention, this all-in-one solution ensures your dog is protected with just one monthly dose.

Fast and Effective

Simparica Trio begins killing fleas within four hours and continues to act as a persistent repellent against ticks and fleas. This quick and effective action ensures that your dog stays comfortable and parasite-free in no time.

Safe for Puppies

Simparica Trio is safe for puppies as young as eight weeks old and weighing at least 2.8 pounds, making it an excellent choice for starting your dog’s parasite protection early.

Complete Protection in One Dose

Simparica Trio contains three active ingredients—sarolaner, moxidectin, and pyrantel—that provide complete protection. Whether it’s fleas, ticks, hookworms, or heartworm prevention, this all-in-one solution ensures your dog is protected with just one monthly dose.

Fast and Effective

Simparica Trio begins killing fleas within four hours and continues to act as a persistent repellent against ticks and fleas. This quick and effective action ensures that your dog stays comfortable and parasite-free in no time.

Safe for Puppies

Simparica Trio is safe for puppies as young as eight weeks old and weighing at least 2.8 pounds, making it an excellent choice for starting your dog’s parasite protection early.

Conclusion

With Simparica Trio, you’re choosing a reliable and proven solution for keeping your dog protected from parasites. Easy to administer and highly effective, Simparica Trio offers peace of mind for a healthier, happier pet.

Conclusion

With Simparica Trio, you’re choosing a reliable and proven solution for keeping your dog protected from parasites. Easy to administer and highly effective, Simparica Trio offers peace of mind for a healthier, happier pet.

Frequently Asked Questions

What is Simparica Trio used for?

It is a monthly oral chewable tablet utilized to prevent heartworm disease, kill fleas and ticks, and treat intestinal roundworms and hookworms in dogs.

What are the active ingredients?

It combines sarolaner (for fleas and ticks), moxidectin (for heartworms and mites), and pyrantel (for intestinal roundworms and hookworms).

How often should Simparica Trio be given?

It is administered orally once every month year-round, matched precisely to your dog’s current body weight following veterinary guidance.

Order Simparica Trio Chewable Tablets Online

Simparica Trio Chewable Tablets for Dogs are available for order through our platform subject to veterinary prescription verification and regulatory compliance. For assistance regarding prescription submission, weight tier selection, or secure shipping protocols, please contact our customer support team.