ReBalance (Sulfadiazine & Pyrimethamine) Antiprotozoal Oral Suspension, 1 Quart (946 mL)

ReBalance Oral Suspension is a specialized veterinary antiprotozoal therapeutic formulation engineered for the systemic treatment of Equine Protozoal Myeloencephalitis (EPM) in horses. Combining two potent synergistic antimicrobial agents, this professional-grade medication inhibits sequential steps in protozoal folic acid synthesis, effectively targeting and eliminating Sarcocystis neurona within the central nervous system. Because EPM is a serious neurological condition requiring prolonged systemic therapy and precise clinical monitoring, administration must be guided by accurate veterinary diagnosis and strict adherence to safety protocols.

What Is ReBalance Oral Suspension?

ReBalance is a specialized veterinary anti-parasitic compound formulated for oral delivery under professional veterinary supervision.

Active Ingredients and Formulation

• Active Components: A combination of sulfadiazine (250 mg/mL) and pyrimethamine (12.5 mg/mL) in an aqueous oral suspension. This synergistic dual-action formula blocks folate metabolism in protozoal organisms, halting parasite reproduction and central nervous system infection.

• Vehicle and Presentation: Supplied as a palatable oral suspension in a 1-quart (946 mL) multi-dose bottle designed for convenient daily dosing.

What Is It Used For?

Primary Veterinary Indications

• Equine Protozoal Myeloencephalitis (EPM): Routinely prescribed by equine veterinarians as a primary medical therapy for clinical EPM caused by Sarcocystis neurona.

• Neurological Recovery Support: Helps halt the progression of protozoal-induced lesions in the brain and spinal cord, restoring coordination, balance, and neurological function in affected horses.

Administration and Dosage Considerations

Route and Dosing

• Route of Administration: Administered orally, either directly into the mouth using an appropriate dosing syringe or mixed into a small portion of feed to ensure complete consumption.

• Standard Equine Dosage Reference: Typically administered at a dose of 20 mg/kg sulfadiazine and 1.0 mg/kg pyrimethamine (equivalent to 20 mL of suspension per 250 lb of body weight) once daily.

• Treatment Duration: Therapy is typically maintained for 90 consecutive days, or as specifically directed by a licensed veterinarian based on clinical response and diagnostic re-evaluation.

• Veterinary Supervision: Dosage adjustments and treatment length must be determined and monitored exclusively by a qualified veterinarian.

Important Safety Information

• Contraindications: Do not administer to horses with known hypersensitivity to sulfonamides or pyrimethamine. Contraindicated in pregnant mares due to potential antifolate teratogenic risks.

• Side Effects and Precautions: Potential side effects include bone marrow suppression (anemia, leukopenia, thrombocytopenia) during prolonged use; periodic complete blood counts are recommended. Mild gastrointestinal upset or skin rashes may occasionally occur.

• Withdrawal Periods: Observe mandatory meat withdrawal intervals established by regulatory authorities if treating food-producing equines intended for human consumption (typically several days following the final dose, depending on regional regulations).

• Professional Guidance: Due to the complex nature of EPM and the duration of therapy, use must be managed under direct veterinary clinical oversight.

Storage and Handling

• Store at controlled room temperature between 15°C and 30°C (59°F to 86°F). Shake well before each use.

• Protect the bottle from freezing and direct sunlight.

• Keep securely out of reach of children, unauthorized individuals, and animals at all times.

Frequently Asked Questions

What is ReBalance Oral Suspension used for?

It is a professional equine antiprotozoal liquid utilized to treat Equine Protozoal Myeloencephalitis (EPM) caused by Sarcocystis neurona.

What are the active ingredients?

It contains sulfadiazine (250 mg/mL) and pyrimethamine (12.5 mg/mL), which work synergistically to block folate synthesis and eliminate protozoal parasites in the central nervous system.

How is ReBalance administered?

It is administered orally once daily at weight-based dosing guidelines, typically for a 90-day course under veterinary supervision.

Order Rx ReBalance Oral Suspension Online

Rx ReBalance (Sulfadiazine & Pyrimethamine) Antiprotozoal Oral Suspension (1 Quart) is available for order through our platform subject to veterinary prescription verification and regulatory compliance. For assistance regarding prescription submission, stock availability, or secure shipping protocols, please contact our customer support team.