NexGard Plus (Afoxolaner, Moxidectin, and Pyrantel) Chewable Tablets for Dogs

NexGard Plus Chewable Tablets are an advanced veterinary antiparasitic medication formulated for monthly oral administration in dogs and puppies to prevent heartworm disease, kill adult fleas, treat and control tick infestations, and treat and control roundworms and hookworms. Combining three active pharmaceutical agents—afoxolaner, moxidectin, and pyrantel—this comprehensive, beef-flavored chewable provides broad-spectrum protection against both external and internal parasites in a single monthly dose. Because multi-parasite prevention requires accurate weight-based dosing and pre-treatment veterinary health screening, administration must follow strict product labeling and clinical supervision.

What Is NexGard Plus?

NexGard Plus is a specialized veterinary triple-action parasiticidal compound formulated for monthly oral delivery under professional veterinary supervision.

Active Ingredients and Formulation

• Active Components:

  • Afoxolaner: An isoxazoline ectoparasiticide that kills adult fleas and treats and controls black-legged ticks, American dog ticks, lone star ticks, and brown dog ticks by targeting insect and acarine nervous systems.

  • Moxidectin: A macrocyclic lactone endoparasiticide that prevents heartworm disease by eliminating the tissue larval stage of Dirofilaria immitis acquired within the past 30 days, while also contributing to the control of certain intestinal parasites.

  • Pyrantel (as pyrantel pamoate): A broad-spectrum anthelmintic that removes and controls adult roundworms (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala).

• Vehicle and Presentation: Supplied as soft, highly palatable beef-flavored chewable tablets packaged in blister packs of 3 or 6 counts, formulated across four distinct weight tiers for dogs and puppies 8 weeks of age and older weighing 4.0 lbs or more.

What Is It Used For?

Primary Veterinary Indications

• Heartworm Disease Prevention: Routinely prescribed by veterinarians to prevent fatal canine heartworm disease.

• Flea and Tick Control: Kills newly emerged adult fleas before they can lay eggs and treats and controls four major tick species for a full 30 days.

• Intestinal Worm Elimination: Treats and controls adult roundworms and hookworms, reducing clinical infection risks and zoonotic exposure.

Features:

• One-and-Done Monthly Dosing: Convenient monthly dosing for full parasite protection.
• Flea Protection: Kills adult fleas before they can lay eggs, preventing infestations.
• Tick Protection: Kills 4 species of ticks: black-legged ticks, brown dog ticks, American dog ticks, and lone star ticks.
• Heartworm Prevention: Effectively prevents heartworm disease in dogs.
• Roundworm & Hookworm Treatment: Treats and controls 3 species of hookworms and 2 species of roundworms.
• Tasty Chew: A delicious beef-flavored, soft chew that dogs love.
• Safe for Puppies: Safe for puppies as young as 8 weeks of age.

Directions: Give orally once a month for continuous parasite protection.

Administration and Dosage Considerations

Route and Dosing

• Route of Administration: Administered orally once a month, with or without food, in a savory chew format that dogs accept readily.

• Weight-Based Dosing Tiers:

  • 4.0 to 8.5 lbs (Yellow box)

  • 8.6 to 25.0 lbs (Purple box)

  • 25.1 to 60.0 lbs (Red box)

  • 60.1 to 121.0 lbs (Green box)

• Veterinary Supervision: For dogs weighing over 121 lbs, administer the appropriate combination of chews. All dogs must be tested for existing heartworm infections by a licensed veterinarian prior to initiating preventative therapy.

Important Safety Information

• Contraindications: Do not use in cats or other animal species. Do not administer to dogs with known hypersensitivity to afoxolaner, moxidectin, or pyrantel. Do not give to puppies under 8 weeks of age or weighing less than 4 lbs.

• Side Effects and Precautions: Exceptionally well tolerated. Rare adverse reactions observed in clinical trials include vomiting, diarrhea, lethargy, or decreased appetite. As an isoxazoline-containing product, use with caution in dogs with a history of neurological disorders, tremors, or seizures.

• Professional Guidance: Ensure dogs consume the entire chew and do not lose fragments to guarantee full therapeutic efficacy throughout the monthly dosing cycle.

Storage and Handling

• Store at controlled room temperature between 15°C and 30°C (59°F to 86°F), with excursions permitted. Protect product from excessive moisture and light.

• Keep individual chewables stored in their protective blister packaging until ready for immediate administration.

• Keep securely out of reach of children, unauthorized individuals, and pets to prevent accidental overconsumption.

Frequently Asked Questions

What is NexGard Plus used for?

It is a monthly oral beef-flavored chewable utilized to prevent heartworm disease, kill fleas, eliminate ticks, and treat roundworms and hookworms in dogs.

What are the active ingredients?

It combines afoxolaner (for fleas and ticks), moxidectin (for heartworms), and pyrantel (for roundworms and hookworms).

How often should NexGard Plus be given?

It is administered orally once every month year-round, matched precisely to your dog’s current body weight following veterinary guidance.

Order NexGard Plus Chews Online

Rx NexGard Plus Chewable Tablets for Dogs are available for order through our platform subject to veterinary prescription verification and regulatory compliance. For assistance regarding prescription submission, weight tier selection, or secure shipping protocols, please contact our customer support team.