Osphos (Clodronate Injection) for Horses, 60 mg/mL, 15 mL

Osphos is a specialized veterinary bisphosphonate formulation engineered to control the clinical signs associated with navicular syndrome in horses by regulating bone resorption and inhibiting osteoclast activity. Delivered as a single intramuscular injection, this professional-grade therapeutic preparation targets areas of heightened bone turnover within the navicular bone, helping to restore normal bone remodeling balance. Because bisphosphonates possess potent physiological activity and long-term skeletal retention, administration requires precise veterinary evaluation, accurate weight verification, and strict adherence to clinical safety guidelines.

What Is Osphos Injection?

Osphos is a specialized veterinary bone-active compound formulated for parenteral administration under professional veterinary supervision.

Active Ingredients and Formulation

• Active Component: Clodronate disodium at a concentration of 60 mg/mL (totaling 900 mg of active clodronate in the standard 15 mL vial). It acts as a non-amino bisphosphonate that binds to hydroxyapatite crystals in bone, inhibiting osteoclast-mediated bone resorption.

• Vehicle and Presentation: Supplied as a sterile, clear aqueous injectable solution in a single-dose 15 mL glass or polymer vial designed exclusively for intramuscular administration.

What Is Osphos Used For?

Primary Veterinary Indications

• Navicular Syndrome Management: Routinely utilized by equine veterinarians to alleviate lameness and improve overall comfort in adult horses suffering from navicular disease (caudal heel pain / navicular bone degeneration).

• Skeletal Remodeling Regulation: Formulated to modulate abnormal bone resorption and remodeling processes within the distal sesamoid (navicular) bone and associated structures.

Administration and Dosage Considerations

Route and Dosing

• Route of Administration: Administered exclusively via intramuscular (I.M.) injection. Divide the total dose into multiple injection sites to minimize localized muscle discomfort.

• Standard Equine Dosage Reference: Administered at a standard dose of 1.8 mg per kg of body weight (up to a maximum dose of 900 mg / 15 mL total per horse weighing 500 kg or more), given as a single treatment course.

• Injection Technique: Administer into large muscle masses (such as the neck or hindquarters), utilizing strict aseptic technique and sterile needles.

• Veterinary Supervision: Must be administered solely by or under the direct supervision of a licensed veterinarian following a thorough lameness examination and diagnostic confirmation of navicular syndrome.

Important Safety Information

• Contraindications: Do not administer to horses with impaired renal function, dehydration, or a known hypersensitivity to clodronate disodium or other bisphosphonates. Do not use in growing horses (under 4 years of age) or pregnant/lactating mares, as bone turnover is critical during development.

• Side Effects and Precautions: Transient clinical signs can occur within hours post-injection, including mild signs of discomfort, restlessness, pawing, sweating, or muscle fasciculations. Monitor horses closely following administration. Concurrent use with NSAIDs should be managed carefully to avoid renal stress.

• Withdrawal Periods: Observe mandatory meat and milk withdrawal intervals established by local regulatory authorities if treating food-producing equines intended for human consumption.

• Professional Guidance: Due to its systemic pharmacological action on bone metabolism, use must be managed under direct veterinary clinical oversight.

Storage and Handling

• Store at controlled room temperature between 20°C and 25°C (68°F to 77°F), with excursions permitted between 15°C and 30°C (59°F to 86°F). Protect from freezing.

• Inspect the vial prior to use; do not use if particulate matter or discoloration is present.

• Keep securely out of reach of children, unauthorized individuals, and animals at all times.

Frequently Asked Questions

What is Osphos used for?

It is a professional equine bisphosphonate injection utilized to treat and control the clinical signs of lameness associated with navicular syndrome in adult horses.

What is the active ingredient?

It contains clodronate disodium at 60 mg/mL, which binds to bone minerals to inhibit excessive bone resorption by osteoclasts.

How is Osphos administered?

It is administered via intramuscular injection, typically divided across multiple injection sites, at a dosage of 1.8 mg/kg under veterinary supervision.

Order Rx Osphos Online

Rx Osphos Injection (60 mg/mL, 15 mL) is available for order through our platform subject to veterinary prescription verification and regulatory compliance. For assistance regarding prescription submission, stock availability, or secure shipping protocols, please contact our customer support team.