Pentosan Polysulfate (Generic) Injection, 250 mg/mL, 6 mL Vial

Pentosan Polysulfate (PPS) Injection is a specialized semi-synthetic polysulfated glycosaminoglycan (GAG) formulated for intramuscular or subcutaneous administration in dogs, horses, and cats to alleviate joint pain and inflammation associated with osteoarthritis and degenerative joint disease. Acting as a chondroprotective agent, PPS stimulates cartilage matrix synthesis, inhibits cartilage-degrading enzymes (such as matrix metalloproteinases), and enhances joint fluid viscosity to restore mobility and comfort. Because of its systemic anticoagulant and chondroprotective properties, administration requires precise veterinary evaluation, individualized weight-based dosing, and strict adherence to clinical safety guidelines.

What Is Pentosan Polysulfate Injection?

Pentosan polysulfate is a specialized veterinary disease-modifying osteoarthritis drug (DMOAD) formulated for parenteral administration under professional veterinary supervision.

Active Ingredients and Formulation

• Active Component: Sodium pentosan polysulfate at a concentration of 250 mg per mL (totaling 1,500 mg per 6 mL vial). It acts as a structural analogue of cartilage matrix mucopolysaccharides, promoting tissue repair and suppressing inflammatory mediators within the synovial joint environment.

• Vehicle and Presentation: Supplied as a sterile, clear aqueous injectable solution in a single-dose or multi-dose 6 mL glass vial designed for aseptic veterinary dispensing.

What Is It Used For?

Primary Veterinary Indications

• Osteoarthritis and Joint Degeneration: Routinely utilized by veterinarians to manage chronic lameness, pain, and stiffness associated with osteoarthritis in dogs, horses, and cats.

• Chondroprotection and Joint Repair: Stimulates synovial fibroblast synthesis of hyaluronic acid, improves intra-articular lubrication, and helps preserve articular cartilage integrity in working, performance, and senior animals.

Administration and Dosage Considerations

Route and Dosing

• Route of Administration: Administered via intramuscular (I.M.) injection or subcutaneous (S.C.) injection, depending on the target species.

• Standard Dosage Reference:

  • Equine Dosage: Typically administered at 3 mg per kg (1.4 mg per lb) of body weight by intramuscular injection, given at weekly intervals for 4 consecutive injections.

  • Canine Dosage: Typically administered at 3 mg per kg (1.3 mg per lb) by subcutaneous injection once weekly for 4 consecutive weeks.

• Veterinary Supervision: Treatment courses, repetition schedules, and injection protocols must be prescribed and monitored exclusively by a licensed veterinarian.

Important Safety Information

• Contraindications: Do not administer to animals with known hypersensitivity to pentosan polysulfate, bleeding disorders (such as von Willebrand’s disease), active systemic hemorrhages, or severe renal/hepatic impairment. Use with caution in animals scheduled for surgery due to mild anticoagulant activity.

• Side Effects and Precautions: Mild transient injection-site discomfort or transient lethargy may occasionally occur. Because PPS possesses mild heparin-like anticoagulant properties, monitor clotting parameters if administered alongside other blood-thinning agents.

• Withdrawal Periods: Observe mandatory meat and milk withdrawal intervals established by regulatory authorities if treating food-producing equines intended for human consumption.

• Professional Guidance: Due to its active systemic pharmacological profile, use must be managed under direct veterinary clinical oversight.

Storage and Handling

• Store at controlled room temperature between 15°C and 30°C (59°F to 86°F), protected from direct sunlight and freezing temperatures.

• Maintain strict aseptic technique when puncturing the vial to prevent microbial contamination.

• Keep securely out of reach of children, unauthorized individuals, and animals at all times.

Frequently Asked Questions

What is Pentosan Polysulfate Injection used for?

It is a professional veterinary chondroprotective injection utilized to reduce joint pain, inflammation, and cartilage degradation associated with osteoarthritis in dogs, cats, and horses.

What is the active ingredient?

It contains sodium pentosan polysulfate at 250 mg/mL, a glycosaminoglycan that stimulates cartilage repair and improves joint fluid viscosity.

How is the injection administered?

It is administered via intramuscular or subcutaneous injection once weekly for a 4-week course following precise weight-based guidelines under veterinary supervision.

Order Rx Pentosan Polysulfate Injection Online

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